Characterisation of GATA2 in blood development and leukaemia

Dr Salima (Sarah) Nurmohamed, University of Oxford and John Goldman Fellow 2015

The GATA2 protein helps regulate blood cell development and has two main functions: it binds DNA to switch genes on or off, and can simultaneously associate with other proteins to regulate genes. If either of these functions are disrupted, it can alter the development of blood cells in the body. Many mutations of the GATA2 protein have been identified, but it is still not known how these errors cause leukaemia. 

Dr Nurohamed's work aims to decipher the mechanisim of the GATA2 protein in normal blood development and explain how these GATA2 mutations cause Acute Myeloid Leukaemia. From the results of this research, we hope to progress the design and development of new and improved treatments. 

I am most honoured to have been awarded the John Goldman Fellowship for Future Science. The John Goldman award will allow me to pursue a vision to bridge scientific fields through collaboration, developing diversity that is key to find a cure for leukaemia.

Dr Salima (Sarah) Nurohamed