Autophagy-dependent regulation of energy metabolism in leukaemia stem cells

Dr Vignir Helgason, Wolfson Wohl Cancer Research Centre, University of Glasgow and John Goldman Fellow 2015

The identification of leukaemic stem cells (LSCs) in the late 1990's supported the idea that leukaemia is primarily driven by the presence of a collection of rare cancer cells in the blood. Since then, many leukaemia treatments have been evaluated on their ability to reduce the number of leukaemia cells. However, if the treatments are not killing LSCs, then the cancerous cells may develop drug resistance, causing relapse. 

Chronic Myeloid Leukaemia (CML) patients are currently treated with drugs called Tyrosine Kinase Inhibitors (TKIs), that inhibit the function of the cancer forming protein BCR-ABL. We have recently seen that CML LSCs can survive TKI treatment, indicating that this therapy alone may not lead to a cure. 

A combination of treatments is therefore required to cure CML, Dr Helgason's research will investigate vulnerabilities in CML LSCs and aim to identify new treatments for the eradication of the leukaemic stem cells. 

My research focusses on the process in which the body destroys its own cells, aiming to find a cure for CML, rather than managing the disease.

Dr Vignir Helgason